The Coller School of Management of Tel Aviv University hosted the 2017 Annual European SPES Conference in September 4-6, 2017 in Tel Aviv, Israel. Collaborative partners were the European SPES Institute and the Business Ethics Center of the Corvinus University of Budapest. The conference addressed spirituality and faith traditions as they fertilize business and enterpreneurs for creating models for pressing social problems, including poverty, conflict, unemployment, environmental degradation and climate change. A new ethos of entrepreneurship needs to be developed in which caring for fellow human beings, future generations and nature play a primordial role. Practical wisdom of the Jewish and other faith traditions suggests that enterprises with a spiritual value orientation can flourish, and serve the interests of business and the wider community better than conventional enterprises following the narrow financial bottom line.